Play therapy

Play therapy techniques are valuable tools for a variety of professionals who work with children. One need not be a registered play therapist to implement play techniques when working with child clients. There are many types of clients that would benefit from play therapy. There are several different theoretical approaches, but the researcher chose to focus on Adlerian Play Therapy, Client-Centered Play Therapy, Cognitive-Behavioral Play Therapy, and Psychodynamic Play Therapy. The paper considers the best location to implement play techniques, by urging the counselor to be aware of the setting\u27s location within the building, ease of cleaning, available space, and what play mediums are available to the child

Complexity and the Characterisation of Learning

Complexity theory offers an alternative to the simple causality and reductive accounts of change which dominate contemporary policy and practice. It does so by recognising that the interplay of dynamic elements results in the emergence of patterns and meanings that cannot be predicted by considering those elements in isolation. This symposium will show how complexity contests what it means to educate, and how it is related to existing philosophical traditions. This is the third of four papers presented at the workshop. It uses insights from complexity theory, along with the work of Gilles Deleuze, to critique existing characterisations of learning

Thyroxine differentially modulates the peripheral clock: lessons from the human hair follicle

The human hair follicle (HF) exhibits peripheral clock activity, with knock-down of clock genes (BMAL1 and PER1) prolonging active hair growth (anagen) and increasing pigmentation. Similarly, thyroid hormones prolong anagen and stimulate pigmentation in cultured human HFs. In addition they are recognized as key regulators of the central clock that controls circadian rhythmicity. Therefore, we asked whether thyroxine (T4) also influences peripheral clock activity in the human HF. Over 24 hours we found a significant reduction in protein levels of BMAL1 and PER1, with their transcript levels also decreasing significantly. Furthermore, while all clock genes maintained their rhythmicity in both the control and T4 treated HFs, there was a significant reduction in the amplitude of BMAL1 and PER1 in T4 (100 nM) treated HFs. Accompanying this, cell-cycle progression marker Cyclin D1 was also assessed appearing to show an induced circadian rhythmicity by T4 however, this was not significant. Contrary to short term cultures, after 6 days, transcript and/or protein levels of all core clock genes (BMAL1, PER1, clock, CRY1, CRY2) were up-regulated in T4 treated HFs. BMAL1 and PER1 mRNA was also up-regulated in the HF bulge, the location of HF epithelial stem cells. Together this provides the first direct evidence that T4 modulates the expression of the peripheral molecular clock. Thus, patients with thyroid dysfunction may also show a disordered peripheral clock, which raises the possibility that short term, pulsatile treatment with T4 might permit one to modulate circadian activity in peripheral tissues as a target to treat clock-related disease

Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy.

Bryostatin 1 is a marine natural product under investigation for HIV/AIDS eradication, the treatment of neurological disorders, and enhanced CAR T/NK cell immunotherapy. Despite its promising activity, bryostatin 1 is neither evolved nor optimized for the treatment of human disease. Here we report the design, synthesis, and biological evaluation of several close-in analogs of bryostatin 1. Using a function-oriented synthesis approach, we synthesize a series of bryostatin analogs designed to maintain affinity for bryostatin's target protein kinase C (PKC) while enabling exploration of their divergent biological functions. Our late-stage diversification strategy provides efficient access to a library of bryostatin analogs, which per our design retain affinity for PKC but exhibit variable PKC translocation kinetics. We further demonstrate that select analogs potently increase cell surface expression of CD22, a promising CAR T cell target for the treatment of leukemias, highlighting the clinical potential of bryostatin analogs for enhancing targeted immunotherapies

Larger portions make me eat more : awareness of the external factors that influence food intake

There is consistent evidence that the amount of food people consume can be influenced by external factors, such as food portion size or the amount of food others are eating. However research studies to date have suggested that people are generally unaware of the influence that these external factors have on food intake. In the present research we directly tested whether consumers are aware of how external factors can affect their food intake. In Study 1 we re-analysed data from a study in which an effect of portion size on food intake was observed and post-consumption, participants were asked whether they believed portion size had influenced their food intake. In Study 2 participants were asked to indicate whether several different external factors known to increase food intake would be likely to increase, decrease or have no effect on how much they would eat in hypothetical scenarios. In Study 1, a large proportion of participants (56%) believed that their food intake was influenced by portion size. In Study 2, a large proportion of participants accurately identified that external factors known to affect eating behaviour would be likely to increase their food intake: portion size (73%), social influence (40%), food variety (75%), and distraction (59%). Together these results suggest that consumers show awareness of the influence that external factors have on their food intake

Providing accessibility through implementation of electronic laboratory notebooks

Electronic Laboratory Notebooks (ELNs) have recently gained popularity in academia and industry while paper laboratory notebooks (PLNs) are becoming obsolete from the digital world. This is due to the many benefits of ELNs such as efficiency, accessibility, and data integrity (Bird, Willoughby, & Frey, 2013; Colabroy & Bell, 2019). In tertiary education, ELNs have been implemented to help students develop skills that are easily transferrable and prepare them for a technological rich workplace. Learning and understanding students’ and teaching staff perceptions’ of their experience with using ELNs, particularly during the COVID-19 pandemic, is key to successful implementation in education. A series of surveys were distributed and interviews were conducted across various undergraduate chemistry units from first to third year level and post-graduate teaching staff to gather insight into their perceptions of using PLNs and ELNs and the software platform, LabArchives. This presentation will provide some insight into students’ and teaching staff’s experiences with using ELNs. In general, it was found that students had positive perceptions of ELNs, even though there is a higher learning curve compared to PLNs. Reasons for this include increased communication, accessibility, and the ease of presenting work legibility. Also, the COVID-19 pandemic is associated with students having a positive experience with using ELNs mainly due to increased communication and accessibility from home where otherwise not possible. REFERENCES Bird, C. L., Willoughby, C., & Frey, J. G. (2013). Laboratory notebooks in the digital era: The role of ELNs in record keeping for chemistry and other sciences. Chemical Society Review, 42(20), 8157-8175. Colabroy, K. & Bell, J. K. (2019). Lab eNotebooks. In Biochemistry Education: From Theory to Practice, 1337, 173-195. American Chemical Society